ska-blocks plugin comes with controls for editing Tailwind configuration.
The controls can be accessed from ska-blocks Block Editor plugin item in the top right corner of the Block Editor screen, in the Tailwind tab:
When you change Tailwind configuration, all blocks and presets will automatically re-compile to ensure they are using the latest Tailwind configuration. For that reason, when you update the Tailwind configuration you may need to save changes twice in a row – once to apply the new configuration, second time to save all the re-compiled CSS.
When you go to change another post or a template then the blocks will also automatically re-compile if the configuration has changed in the meantime.
Tailwind theme
For extending the CSS-based Tailwind 4 theme you can add overrides to the Custom theme option.
Color and typography options have a separate UI for easier editing.